CA2067475C — Carbostyril derivatives and their use

USPTO Abstract

Disclosed are carbostyril derivatives of the general formula (see above formula) wherein R1a is a halogen or a lower alkoxy, lower alkyl, lower alkenyloxy, amino, lower alkanoylamino or lower alkylthio group; R2 is a phenyl group which optionally may have one or two substituents each independently selected from the group consisting of halogen, lower alkoxy, lower alkyl, nitro, amino, lower alkanoylamino, hydroxyl, cyano, phenyl-lower alkoxy and halo-lower alkyl; A is a lower alkylene group; and the carbon-carbon bond between the positions 3 and 4 of the carbostyril skeleton is a single bond or a double bond; and salts thereof, and pharmaceutical compositions containing the same, for use as a disturbance-of-consciousness improving agent, central nervous system stimulent or sigma receptor agonist.