CA2015761A1 — Method of preparing chiral .beta.-amino acids
Assigned to Monsanto Co · Expires 1990-11-01 · 36y expired
What this patent protects
07-21(490)A METHOD OF PREPARING CHIRAL B-AMINO ACIDS ABSTRACT The present invention is directed to asym-metric synthesis of .beta.-amino acids wherein Curtius rearrangement of 2(R)-mono-substituted succinates is effected and the incipient isocyanate is tra…
USPTO Abstract
07-21(490)A METHOD OF PREPARING CHIRAL B-AMINO ACIDS ABSTRACT The present invention is directed to asym-metric synthesis of .beta.-amino acids wherein Curtius rearrangement of 2(R)-mono-substituted succinates is effected and the incipient isocyanate is trapped with a primary or secondary alcohol. The resulting carbamate-protected .beta.-amino esters are then saponified to produce the corresponding carbamate-protected .beta.-amino acids which are deprotected to yield .beta.-amino acids which possess the same absolute configuration as naturally-occurring (L)-amino acids.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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