CA1334975C — Furan and pyrrole containing lipoxygenase inhibiting compounds

USPTO Abstract

Substituted furyl- and pyrrolylhydroxamic acids and N-hydroxyurea compounds of the formula wherein X is oxygen or -NR4 (where R4 is hydrogen, alkyl, alkoyl, arylalkyl or aroyl); A is C1-C6 alkylene or C2-C6 alkenylene; R1 is C1-C4 alkyl, C2-C4 alkenyl, or -NR2R3 where R2 and R3 are independently selected from hydrogen, alkyl hydroxy or substituted or unsubstituted aryl; n is 0, 1, 2 or 3; and Y is independently selected at each occurrence from hydrogen, halogen, hydroxy, cyano C1-C12 alkyl, halosubstituted C1-C12 alkyl, C2-C12 alkoxy, C3-C8 cycloalkyl, and substituted or unsubstituted aryl, aryloxy, arylalkyl, arylalkenyl, arylalkoxy, arylthioalkoxy, alkoxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylalkylamino, arylalkylaminocarbonyl, alkoxyalkoxyalkyl, alkoxyalkyl, and arylalkoxyalkyl are disclosed. The compounds inhibit the action of lipoxygenase enzymes and are useful in the treatment of allergic and inflammatory disease states.