CA1305148C — Carbamoylpyrrolidone derivatives and drugs for senile dementia

USPTO Abstract

ABSTRACT OF TEE INVENTION A compound of the formula: (I) (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group, one of A and B is and the other is: : R1 is hydrogen or C1-C? alkyl; Z1 is phenyl, benzyl, or isoxazolyl each optionally substituted by A halogen, methoxy, or methyl group; Z2 is hydrogen, C1-C? alkyl, C2-C? alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z1 and Z2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group; Z3 is C1-C? hydroxyalkyl, di(C1-C? alkyl)sulfamoyl, 6-membered hetero-cyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group; Z4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z? is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z? is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3) or its pharmaceutical acceptable acid addition salt being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.