CA1049411A — N-substituted pyridone and general method for preparing pyridones

USPTO Abstract

A USEFUL N-SUBSTITUTED PYRIDONE AND GENERAL METHOD FOR PREPARING PYRIDONES ABSTRACT Novel analgesic compositions containing as the active ingredient the compound, 5-methyl-1-phenyl-2-(1-H) pyridone are described, In addition, a general method for the synthesis of aromatic group N-substituted 2(1-H) pyridones is described wherein a 2-(1-H) pyridone, which may be substituted, is reacted with an appropriate halo-aromatic compound in the presence of an alkali metal carbonate and copper powder. The appropriate aromatic N-substituted pyridone is obtained in excellent yield. The aryl N-substituted-2(1-H) pyridones have been found to posess uricosuric activity with the 5-methyl-1-phenyl-2-(1-H) pyridones causing significant lowering of serum uric acid levels. The latter compound caused no irritation on oral administration or when applied to specific target tissues showed no siginificant irritation or other sequelae.