AU658271B2 — Butadiene derivatives and process for preparing the same

USPTO Abstract

Novel butadiene derivatives of the formula [I]: <CHEM> wherein Ring A is tri-lower alkoxyphenyl, R<1> and R<2> combine each other to form a group of the formula: &rdurule& N-R<3> or one of R<1> and R<2> is lower alkoxy, and the other is group of the formula: -NHR<3>, in which R<3> is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof. Among the desired butadiene derivatives [I] of the present invention, the 3-butenoic acid-type compounds per se have antithrombotic activity, but they can also be used as an intermediate for preparing the 2,5-pyrrolidinedione-type compounds having excellent antithrombotic activity. And additionally a butenoic acid ester of the formula [II]: <CHEM> wherein Ring A is a tri-lower alkoxyphenyl group, and one of R<1><2> and R<2><2> is a lower alkoxy group, and the other is hydroxy group, or a salt thereof, as synthetic intermediate.