AU Patent

AU5359496A — Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom

Assigned to Ionis Pharmaceuticals Inc · Expires 1996-09-23 · 30y expired

What this patent protects

Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5' positions. Monomeric sub-units having these modifications may be further modified at the 2' position. Improved processes for the synthesis of 2'-O-substituted py…

USPTO Abstract

Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5' positions. Monomeric sub-units having these modifications may be further modified at the 2' position. Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Drugs covered by this patent

Patent Metadata

Patent number
AU5359496A
Jurisdiction
AU
Classification
—
Expires
1996-09-23
Drug substance claim
No
Drug product claim
No
Assignee
Ionis Pharmaceuticals Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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