AU2025213576A1 — Treatment of hair loss disorders with deuterated JAK inhibitors

USPTO Abstract

#$%^&*AU2025213576A120250821.pdf##### ABSTRACT OF THE DISCLOSURE Disclosed is a method of treating in a subject hair loss disorders that are beneficially treated by administering a JAK1 and/or JAK2 inhibitor. The method comprises administering to the subject an amount in the range of about 4 mg to about 50 mg of Compound (I): or a pharmaceutically acceptable salt thereof. This invention also provides compositions comprising Compound (I) and the use of such compositions in the described methods. ABSTRACT OF THE DISCLOSURE Disclosed is a method of treating in a subject hair loss disorders that are beneficially treated by administering a JAK1 and/or JAK2 inhibitor. The method comprises administering to the subject an amount in the range of about 4 mg to about 50 mg of Compound (I): D DNC DH D N-N D D D D N N N H Compound (I) or a pharmaceutically acceptable salt thereof. This invention also provides compositions comprising Compound (I) and the use of such compositions in the described methods. 20 25 21 35 76 06 A ug 2 02 5 A B S T R A C T O F T H E D I S C L O S U R E D i s c l o s e d i s a m e t h o d o f t r e a t i n g i n a s u b j e c t h a i r l o s s d i s o r d e r s t h a t a r e b e n e f i c i a l l y t r e a t e d b y a d m i n i s t e r i n g a J A K 1 a n d / o r J A K 2 i n h i b i t o r . T h e m e t h o d c o m p r i s e s 2 0 2 5 2 1 3 5 7 6 0 6 2 0 2 5 A u g a d m i n i s t e r i n g t o t h e s u b j e c t a n a m o u n t i n t h e r a n g e o f a b o u t 4 m g t o a b o u t 5 0 m g o f C o m p o u n d ( I ) : D D N C D H D N - N D D D D N N NZI H C o m p o u n d ( I ) o r a p h a r m a c e u t i c a l l y a c c e p t a b l e s a l t t h e r e o f . T h i s i n v e n t i o n a l s o p r o v i d e s c o m p o s i t i o n s c o m p r i s i n g C o m p o u n d ( I ) a n d t h e u s e o f s u c h c o m p o s i t i o n s i n t h e d e s c r i b e d m e t h o d s .