AU2025205457A1 — Osmotic dosage forms comprising deutetrabenazine and methods of use thereof

USPTO Abstract

#$%^&*AU2025205457A120250731.pdf##### ABSTRACT Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once- daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time. ABSTRACT Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once- daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time. 20 25 20 54 57 15 J ul 2 02 5 A B S T R A C T P r o v i d e d h e r e i n a r e o s m o t i c d o s a g e f o r m s c o n t a i n i n g d e u t e t r a b e n a z i n e f o r u s e i n t h e t r e a t m e n t 2 0 2 5 2 0 5 4 5 7 1 5 J u l 2 0 2 5 o f , e . g . , h y p e r k i n e t i c m o v e m e n t d i s o r d e r s . W h e n o r a l l y a d m i n i s t e r e d t o a s u b j e c t o n a o n c e - d a i l y b a s i s , t h e d o s a g e f o r m s p r o v i d e a f a v o r a b l e p h a r m a c o k i n e t i c p r o f i l e f o r t h e a c t i v e a g e n t i n d i c a t i n g t r e a t m e n t e f f i c a c y o v e r a n e x t e n d e d p e r i o d o f t i m e .