AU2025205058A1 — Dosing regimens and related compositions and methods

USPTO Abstract

#$%^&*AU2025205058A120250724.pdf##### Abstract In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects, the invention further provides methods of using cell-reactive compstatin analogs, e.g., treat a complement- mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. In some aspects, the invention further provides methods of using long-acting compstatin analogs, e.g., to treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides targeted compstatin analogs and compositions comprising targeted compstatin analogs. In some aspects, the invention further provides methods of using targeted compstatin analogs, e.g., to treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. Abstract In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects, the invention further provides methods of using cell-reactive compstatin analogs, e.g., treat a complement- mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. In some aspects, the invention further provides methods of using long-acting compstatin analogs, e.g., to treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides targeted compstatin analogs and compositions comprising targeted compstatin analogs. In some aspects, the invention further provides methods of using targeted compstatin analogs, e.g., to treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. 20 25 20 50 58 02 J ul 2 02 5 A b s t r a c t I n s o m e a s p e c t s , t h e p r e s e n t i n v e n t i o n p r o v i d e s c e l l - r e a c t i v e c o m p s t a t i n a n a l o g s a n d 2 0 2 5 2 0 5 0 5 8 0 2 J u l 2 0 2 5 c o m p o s i t i o n s c o m p r i s i n g c e l l - r e a c t i v e c o m p s t a t i n a n a l o g s . I n s o m e a s p e c t s , t h e i n v e n t i o n f u r t h e r p r o v i d e s m e t h o d s o f u s i n g c e l l - r e a c t i v e c o m p s t a t i n a n a l o g s , e . g . , t r e a t a c o m p l e m e n t - m e d i a t e d d i s o r d e r , e . g . , t o i n h i b i t c o m p l e m e n t - m e d i a t e d d a m a g e t o a c e l l , t i s s u e , o r o r g a n . I n s o m e a s p e c t s , t h e i n v e n t i o n p r o v i d e s l o n g - a c t i n g c o m p s t a t i n a n a l o g s a n d c o m p o s i t i o n s c o m p r i s i n g l o n g - a c t i n g c o m p s t a t i n a n a l o g s . I n s o m e a s p e c t s , t h e i n v e n t i o n f u r t h e r p r o v i d e s m e t h o d s o f u s i n g l o n g - a c t i n g c o m p s t a t i n a n a l o g s , e . g . , t o t r e a t a c o m p l e m e n t - m e d i a t e d d i s o r d e r , e . g . , t o i n h i b i t c o m p l e m e n t - m e d i a t e d d a m a g e t o a c e l l , t i s s u e , o r o r g a n . I n s o m e a s p e c t s , t h e i n v e n t i o n p r o v i d e s t a r g e t e d c o m p s t a t i n a n a l o g s a n d c o m p o s i t i o n s c o m p r i s i n g t a r g e t e d c o m p s t a t i n a n a l o g s . I n s o m e a s p e c t s , t h e i n v e n t i o n f u r t h e r p r o v i d e s m e t h o d s o f u s i n g t a r g e t e d c o m p s t a t i n a n a l o g s , e . g . , t o t r e a t a c o m p l e m e n t - m e d i a t e d d i s o r d e r , e . g . , t o i n h i b i t c o m p l e m e n t - m e d i a t e d d a m a g e t o a c e l l , t i s s u e , o r o r g a n .