AU2025204785A1 — Methods for treating Arenaviridae and Coronaviridae virus infections

USPTO Abstract

#$%^&*AU2025204785A120250717.pdf##### ABSTRACT OF THE DISCLOSURE Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: , wherein the 1’ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections. ABSTRACT OF THE DISCLOSURE Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: R R¹ R N O N O N R R¹¹¹ RR R¹ R³ R² , wherein the l' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections. 20 25 20 47 85 25 J un 2 02 5 J u n 2 0 2 5 A B S T R A C T O F T H E D I S C L O S U R E P r o v i d e d a r e m e t h o d s f o r t r e a t i n g A r e n a v i r i d a e a n d C o r o n a v i r i d a e v i r u s i n f e c t i o n s b y a d m i n i s t e r i n g n u c l e o s i d e s a n d p r o d r u g s t h e r e o f , o f F o r m u l a I : R 2 0 2 5 2 0 4 7 8 5 2 5 R ¹ R N O N O N R R R R ¹ R ³ R ² , w h e r e i n t h e l ' p o s i t i o n o f t h e n u c l e o s i d e s u g a r i s s u b s t i t u t e d . T h e c o m p o u n d s , c o m p o s i t i o n s , a n d m e t h o d s p r o v i d e d a r e p a r t i c u l a r l y u s e f u l f o r t h e t r e a t m e n t o f L a s s a v i r u s a n d J u n i n v i r u s i n f e c t i o n s .