AU2025204628A1 — Isoxazoline parasiticide formulations and methods for treating blepharitis

USPTO Abstract

#$%^&*AU2025204628A120250710.pdf##### ABSTRACT Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed. ABSTRACT Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed. 20 25 20 46 28 20 J un 2 02 5 A B S T R A C T 2 0 2 5 2 0 4 6 2 8 2 0 J u n 2 0 2 5 D i s c l o s e d h e r e i n a r e m e t h o d s f o r t r e a t i n g o r p r e v e n t i n g o p h t h a l m i c a n d d e r m a t o l o g i c c o n d i t i o n s i n a p a t i e n t , i n c l u d i n g o c u l a r s u r f a c e c o n d i t i o n s s u c h a s b l e p h a r i t i s . T h e m e t h o d s c a n i n c l u d e t o p i c a l l y a d m i n i s t e r i n g d i r e c t l y t o a n o c u l a r s u r f a c e o f o n e o r m o r e e y e s o f a p a t i e n t i n n e e d o f t r e a t m e n t t h e r e o f a n e f f e c t i v e a m o u n t o f a n i s o x a z o l i n e p a r a s i t i c i d e , f o r m a m i d i n e p a r a s i t i c i d e , o r o t h e r a c t i v e i n g r e d i e n t , f o r m u l a t e d i n t o a n o p h t h a l m i c c o m p o s i t i o n , t h e o p h t h a l m i c c o m p o s i t i o n f u r t h e r c o m p r i s i n g a p h a r m a c e u t i c a l l y a c c e p t a b l e v e h i c l e . C o m p o s i t i o n s a r e a l s o d i s c l o s e d .