AU2024219851A1 — Angiotensin II Alone or in Combination for the Treatment of Hypotension

USPTO Abstract

There is described a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least 5 about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-2.0 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or 10 less. There is also described a method of treating a subject suffering from shock, septic shock, shock from cardiac arrest, cardiogenic shock, high output shock, acute kidney injury, hepatorenal syndrome, variceal bleeding, liver cirrhosis, or portal hypertension, comprising administering angiotensin II at an initial rate from about 2 ng/kg/min to about 20 ng/kg/min, followed by administering angiotensin II at a decreased rate.