AU2024207082A1 — Methods for preventing or slowing the progression of cognitive decline or impairment in subjects

USPTO Abstract

Methods for preventing or slowing the progression of cognitive impairment or preventing the development or reducing the rate of cognitive decline. Methods for slowing the volumetric atrophy or reduction of a subregion of the medial temporal lobe. Methods for slowing the volumetric atrophy or reduction of the entorhinal cortex (ERC). Methods for slowing the volumetric atrophy or reduction of the transentorhinal cortex (BA35). The methods comprise administering to an APOE4 non-carrier subject one or more of levetiracetam, brivaracetam or seletracetam, or a pharmaceutically acceptable salt thereof, or administering a pharmaceutical composition comprising levetiracetam, brivaracetam or seletracetam or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.