AU2023202350B2 — Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof

USPTO Abstract

] The present invention provides a pharmaceutical composition containing the following compound having antiviral action: OP O 0 A' ( n (R4)m Pis hydrogen or a group to form a prodrug; A' is CR1AR1B, Sor0; A 2 is CR2AR2B, Sor0; A 3 is CR3AR 3B, Sor0; A 4 is each independently CR4A R41B, S or 0; the number of hetero atoms among atoms constituting the ring which consists of A1 , A2, A 3, A 4, nitrogen atom adjacent to A 1 and carbon atom adjacent to A 4 , is 1 or 2; R1 A and R 1B are each independently hydrogen, halogen, alkyl, or the like; R2 A and R 2 B are each independently hydrogen, halogen, alkyl, or the like; R3 A and R31B are each independently hydrogen, halogen, alkyl, or the like; R4 A and R4B are each independently hydrogen, halogen, alkyl, or the like; R3 A and R3B may be taken together with an adjacent carbon atom to form non aromatic carbocycle or non-aromatic heterocycle; R 1 is fluorine; m is any integer of 1 to 2; and nis anyinteger of1 to 2.