AU2021341936A1 — Formulations of a somatostatin modulator

USPTO Abstract

A spray-dried solid dispersion comprising: (a) 3 - [4 -(4 -amino -piperidin-I-y l)-3 -(3,5 -difluoro-phenyI)- quinolin-6 -yl] -2 -hydroxy-benzonitrile, or a pharmaceutically acceptable salt or solvate thereof; and (b) a pharmaceutically acceptable polymer; wherein said API is dispersed in a polymer matrix formed from the pharmaceutically acceptable polymer. A tablet comprising said the spray-dried solid dispersion and one or more pharmaceutical acceptable ingredients selected from the group consisting of one or more diluents, one or more disintegrants, one or more lubricants, one or more glidants. Said tablet for use in the treatment of acromegaly or neuroendocrine tumors, or both, in a human by oral administration.