AU2020296106B2 — Sulfur functionalized monoliths and particles derived from the same as nitric oxide carriers for pharmaceutical and cosmetic applications

USPTO Abstract

The present application is directed to sulfur-functionalized monoliths and particles derived therefrom as nitric oxide (NO) carriers for applications in drug delivery and cosmetic formulations. An example aspect of the application includes a monolith structure which contains a first monomer having a sulfur functionalized side group linked with a second monomer to form a framework. Another aspect of the application includes a particle having a rough surface derived from the monolith. A further aspect of the application includes the particle having a rough surface which has been reacted to form a nitrosylated particle containing NO covalently attached to a sulfur group. As also described in the application, aspects of the disclosure can include methods for making the monolith structure, methods for deriving a particle or particle having a rough surface from the monolith, and methods for treating a condition using a nitrosylated particle or a particle loaded with NO.