AU Patent

AU2020206884A1 — Modulators of Pin1 activity and uses thereof

Assigned to Yeda Research and Development Co Ltd · Expires 2021-08-05 · 5y expired

What this patent protects

Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety a…

USPTO Abstract

Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety and the rigid moiety are arranged such that the electrophilic moiety is capable of covalently binding to the Cys 113 residue of Pin1, and the rigid moiety is capable of forming hydrogen bonds with the Gin 131 and His 157 residues of Pin1. Further disclosed are novel compounds having Formula Id: Wherein the dashed line, W, X, Y, Z, Ra-Rc, R

Drugs covered by this patent

Patent Metadata

Patent number
AU2020206884A1
Jurisdiction
AU
Classification
—
Expires
2021-08-05
Drug substance claim
No
Drug product claim
No
Assignee
Yeda Research and Development Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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