AU2019324155A1 — Platelet count-agnostic methods of treating myelofibrosis
Assigned to GlaxoSmithKline LLC · Expires 2021-02-18 · 5y expired
What this patent protects
Reanalysis of the SIMPLIFY 1 and 2 trials data indicates MMB is effective in JAKi- naïve patients and in second line therapy to RUX, providing benefits of reducing enlarged spleens, improving myelofibrosis-related symptoms, and increasing transfusion independence in patient at ri…
USPTO Abstract
Reanalysis of the SIMPLIFY 1 and 2 trials data indicates MMB is effective in JAKi- naïve patients and in second line therapy to RUX, providing benefits of reducing enlarged spleens, improving myelofibrosis-related symptoms, and increasing transfusion independence in patient at risk for thrombocytopenia from the underlying disease and RUX therapy. Accordingly, methods of treating myeloproliferative neoplasms (MPN) such as myelofibrosis are described. The methods can include administering a therapeutically effective amount of momelotinib or a pharmaceutically acceptable salt thereof to a subject identified as having (i) myelofibrosis and (ii) a platelet count of less than 150 x l0
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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