AU2019200268A1 — Stabilized modified release vitamin d formulation and method of administering same
Assigned to Opko Ireland Global Holdings Ltd · Expires 2019-02-07 · 7y expired
What this patent protects
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following expos…
USPTO Abstract
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations. See Fig. 1A. WO 2014/143941 PCT/US2014/028132 Figure 1A 30 pg - 25*C/60%RH - Initial 1- 1 month (--1-- 3 months --- 6 months --9*- 9 months -G- 12 months 2 50 -&- 18 months Q 24 months Time (hour) Figure 1B 60 pg - 25 0 C/60% RH - Initial -- 1 month -- 3 months 0 0 100 6 months --- 9 months -- 12 months C -E- 18 months 50, +A 24 month 0+ Time (hour)
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