AU2018203715B2 — Treatment or prevention of cardiovascular events via the administration of a colchicine derivative

USPTO Abstract

TREATMENT OR PREVENTION OF CARDIOVASCULAR EVENTS VIA THE ADMINISTRATION OF A COLCHICINE DERIVATIVE A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof R wherein: R1 , R2 , R3 , R4 , R9, Rio, Ri 1and R1 2 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3.6 cycloalkyl, halogen, C 1 .4 haloalkyl, nitro, amino, C2-4 acylamino, C1 -4 alkyl or dialkylamino, hydroxyl, Ci-4alkoxy, C 1 .4 alkylthio, a group of the formula - SO 2N(R) 2 or SO 2R' where Rx is C 1 .4 alkyl, C 1 .4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy; R7 and R8 independently represent hydrogen, C 1-4 alkyl or C1-4 acyl; and R5 , R5 , R6, and R6 " independently represent hydrogen, C1 -4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C 1 .4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1 .4 alkylthio a group of the formula -SO 2N(Rx)2 or SO 2R' where Rx is C 1.4 alkyl, C 1.4 acyloxy, or optionally substituted phenyl.