AU2016236578B2 — Preparation method of crystalline form a of pci-32765

USPTO Abstract

A preparation method of a PCI-32765 crystal form A. The preparation method comprises the following steps: 1) dissolving free alkali solid of PCI-32765 into a positive solvent; 2) adding a solution in the step 1) in an anti solvent dropwise, stirring after dropwise adding is completed, and adding a crystal seed of the PCI-32765 crystal form A, or adding the solution in the step 1) in suspension liquid containing the crystal seed of the PCI-32765 crystal form A; 3) controlling a solution system obtained in the step 2) to continuously stir, and ageing to obtain crystal magma; and 4) filtering, washing and drying the crystal magma to obtain powder of the PCI-32765 crystal form A. The preparation method has the characteristics of simpleness in process operation, stable and controllable process, high yield, environmental protection, good impurity removing capacity and suitability for industrial production. In addition, the prepared crystal form A can be stably stored, and the hygroscopicity and the solubility of the prepared crystal form A meet the requirements for medicinal use.