AU2016229982A1 — Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy

USPTO Abstract

The present invention relates to methods for treating a disease associated with insulin resistance selected from a nonalcoholic fatty liver disease (NAFLD) and its sequelae, a lipodystrophic syndrome or a combination thereof with the selecti ve PPARy agonist INT 131. and optionally vitamin E or compositions thereof. NAFLBs that may be treated with methods and compositions of the present invention include, but are not limited to, simple nonalcoholie fatty liver and nonalcoholic steatohepatitis (NASH), Lipodystrophic syndromes that may be treated with the methods and compositions of the present invention include, but are not limited to, generalized lipodystrophy including congenital generalized lipodystrophy and acquired generalized lipodystrophy and/or partial lipodystrophy, including congenital partial lipodystrophy and acquired partial lipodystrophy, ail of which may or may not include hyperllpidemia and/or hyperglycemia and may or may not include NAFLD.