AU2015201102B2 — Nasal spray device

USPTO Abstract

A nasal spray device for the delivery of a pharmaceutical formulation to a nasal cavity in metered doses. The device comprises a pressurised aerosol canister 5 including a vial containing a pharmaceutical formulation comprising an active ingredient, a propellant and optionally a co-solvent. The aerosol canister further includes a metering valve having a valve stem. The device also comprises an actuator for the aerosol canister. The actuator includes a stem block having a receptacle into which the valve stem of metering valve of the aerosol canister is 10 received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, and a sump extending below the receptacle. The stem block further defines a discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to 15 pass from the sump to the discharge orifice. The actuator further comprises a delivery outlet for an aerosol plume. The discharge orifice is arranged to direct the aerosol plume through the delivery outlet. The device is adapted to produce an aerosol plume for a dispensed dose having a spray force value no greater than 40 mN measured at a distance of 30 mm from the discharge orifice. The 20 transfer channel has a first part in fluid communication with the sump of the stem block and a second part in fluid communication with the discharge orifice. The second part and the discharge orifice is defined by a separate insert received into an opening formed in the stem block of the actuator. An end of the insert is provided with a radial flange from which a resilient sleeve extends in a 25 coaxial relationship with the second part of the transfer channel and the discharge orifice. The resilient sleeve is received into the opening. 6261117_1 (GHMatters) P92922.AU.1 DENISET / -19 Fig.1I