AU2013203620B2 — Polymorphic forms of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

USPTO Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization Interational Bureau (10) International Publication Number (43) International Publication Date W O 2013/134288 A9 12 September2013 (12.09.2013) W IPO I PCT (51) International Patent Classification: BER, Michael; c/o Gilead Sciences, Inc., 333 Lakeside CO 7D 4 73/34 (2006.01) A61K 31/52 (2006.01) Drive, Foster City, CA 94404 (US) SHI, Bing; c/o Gilead C07D 403/12(2006,01) A6JP 35/02(2006.01) Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (21) International Application Number: (US). SU.HNO, Kelko; c/o Gilead Sciences, Inc., 333 PCT/US2013/029157 Lakeside L)rive, Foster City, CA 94404 (US). TRAN, Duong; c/o Gilead Sciences, Inc., 333 Lakeside Drive, (22) International Filing Date: Foster City, CA 94404 (US). WANG, Fang; d/o Gilead 5 March 2013 (0503.2013) Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (25) Filing Language: English (US). EVARTS, Jerry, B.. (74) Agents: CHOI, Anita et al; Morrison & Foerster LLP, (26) Publication Language: English 755 Page Mill Road, Palo Alto, CA 94304-1018 (US). (30) Priority Data: (81) Designated States (unless otherwise indicated. for every kind ofnational protection available): AE, AG, AL, AM, (71) Applicant: GILEAD CALISTOGA LLC [US/US]; c/o AO, AT, AU, AZ, BA, 1313, BGi, 1311, BN, BR, BPW, BY, Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA BZ, CA, CII, CL, CN, CO, CR, CU, CZ, DE, DK, DM, 94404 (US), DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, 01l, GM, GT, llN, IIR, 11U, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (72) Inventors: CARRA, Ernest; c/o Gilead Sciences, Inc., KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 333 Lakeside Drive, Foster City, CA 94404 (US). GER- ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, [Continued on next page] (54) Title: POLYMORPHIC FORMS OF (S)-2-(1-('91-PURIN-6-YLAMINO)PROPYL)-5-FLUORO-3-PIENYLQUINAZOLIN 4(3H)-ONE (57) Abstract: Polymorphs of (S)-2-(1-(91I-purin-6 ylanino)propyl)-5-lluoro-3-phenylquinazolin- 4(311)-one, composi tions thereof, methods for their preparation, and methods for their usc arc disclosed. Mt 5t}1?47mg r-7.0Up TemperatumGC B--V41 -I 113