AU2012324029B2 — Polymorphs of CDDO ethyl ester and uses thereof

USPTO Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2014/048033 A1 3 April 2014 (03.04.2014) WI PO I P CT (51) International Patent Classification: C1O-1, BDA, 2 North Jingyuan St., Beijing 100176 (CN). C07J63/00 (2006.01) A61P3/04 (2006.01) HAN, Chunlei; C1O-1, BDA, 2 North Jingyuan St., A61K 31/56 (2006.01) A61P 9/12 (2006.01) Beijing 100176 (CN). A61P 35/00 (2006.01) A61P 9/10 (2006.01) (74) Agents: CHEN & PARTNERS et al.; B402, 4/F, Tower A61P 29/00 (2006.01) A61P 13/12 (2006.01) B, Beichen Huixin Plaza, 8 Beichen East Rd., Chaoyang A61P 19/02 (2006.01) A61P 25/00 (2006.01) District, Beijing 100101 (CN). A61P 1/00 (2006.01 ) A61P 27/02 (2006.01 )' ' A61P 9/00 (2006.01) A61P 3/00 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 3/10 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number. AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/CN2012/086045 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 6 December 2012 (06.12.2012) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. PCT/CN2012/082278 28 September 2012 (28.09.2012) CN (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: APPLIED PHARMACEUTICAL SCI- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, ENCE, INC. [CN/CN]; C1O-1, BDA, 2 North Jingyuan UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, St., Beijing 100176 (CN). WANG, Zhijian [CN/CN]; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, C10-1, BDA, 2 North Jingyuan St., Beijing 100176 (CN). EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventor; and MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (71) Applicant: ZHANG, Xiaohong [US/CN]; C1O-1, BDA, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 2 North Jingyuan St., Beijing 100176 (CN). ML, MR, NE, SN, TD, TG). (72) Inventors: LU, Song; C1O-1, BDA, 2 North Jingyuan St., Published: Beijing 100176 (CN). SUN, Wendong; C10-1, BDA, 2 - with international search report (Art. 21(3)) North Jingyuan St., Beijing 100176 (CN). LIU, Kaiyang; (54) Title: POLYMORPHS OF CDDO ETHYL ESTER AND USES THEREOF CO2Et NC (57) Abstract: The present invention relates to polymorphic forms of the compound of Formula (I) (i.e., ethyl 2-cyano-3,12-diox O oleana-1,9(ll)-dien-28-oate (CDDO ethyl ester)) and methods of using them for treating a variety of disease states such as cancer and condisitons associated with inflammation.