AU2009224801B2 — Modified release composition comprising doxofylline

USPTO Abstract

The invention concerns a modified release doxofylline-based pharmaceutical composition, for administration once a day only. The composition contains doxofylline, in combination with a polymer chosen from a pharmaceutically acceptable cellulose derivative, a pharmaceutically acceptable methacrylate derivative, their mixtures, and pharmaceutically acceptable salts thereof; the composition may also comprise lubricating agents, such as magnesium stearate, and filling agents, such as lactose, talc, microcrystalline cellulose. The present composition provides a plasmatic concentration bioequivalent to that achieved by the immediate release composition currently available on the market, but at a lower dosage of the active ingredient.