AU2006291836B2 — RNA antagonist compounds for the inhibition of Apo-Bl00 expression
Assigned to Roche Innovation Center Copenhagen AS · Expires 2012-02-23 · 14y expired
What this patent protects
Oligonucleotides directed against the Apo-B100 gene are provided for modulating the expression of Apo-B100. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Apo-Bl00. Methods of using these compounds for m…
USPTO Abstract
Oligonucleotides directed against the Apo-B100 gene are provided for modulating the expression of Apo-B100. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Apo-Bl00. Methods of using these compounds for modulation of Apo-Bl00 expression and for the treatment of diseases associated with either overexpression of Apo-Bl00, expression of mutated Apo-Bl00 or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.
Drugs covered by this patent
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