AU2006289281B2 — Pyridine derivatives and their use in the treatment of psychotic disorders

USPTO Abstract

There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: X represents a nitrogen atom; Y represents -C(H)-, (-C(H)-), -S(O)- or -C(=O)-; Z represents -C(H)-, -S(O)-, -N(R)-, or an oxygen or sulphur atom; A represents hydrogen or -CHOH; R represents hydrogen, Calkyl, Calkoxy, -COR7 or -SO2R7; R represents halogen, Calkyl, Calkoxy, =O, haloCalkyl, haloCalkoxy, hydroxyl or -CHOH; m represents an integer from 0 to 3; R represents halogen, =O, Calkyl (optionally substituted by one or more hydroxyl groups), -COOR, -CONRR, Calkoxy, haloCalkyl, haloCalkoxy or CalkyloCalkyl; n represents an integer from 0 to 3; p and q independently represent an integer from 0 to 2; R represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, Calkyl (optionally substituted by one or more hydroxyl groups), Ccycloalkyl, Calkoxy, hydroxyl, haloCalkyl, haloCalkoxy, cyano, -S-Calkyl, -SO-Calkyl, -SO-Calkyl, -COR, -CONRR, -NRR, -NRCOCalkyl, -NRSO-Calkyl, Calkyl-NRR, -OCONRR , -NRCOR or -SONRR groups; R and R independently represent Calkyl, or R and R together with the carbon atom to which they are attached may together form a Ccycloalkyl group; R6 represents halogen, Calkyl, Ccycloalkyl, Calkoxy, haloCalkyl or haloCalkoxy; s represents an integer from 0 to 4; R and R independently represent hydrogen, Calkyl or Ccycloalkyl; or solvates thereof.