Primary endpoint
The pre-specified outcome measure used to determine whether a trial succeeded.
Definition
The primary endpoint is the principal outcome measure used to assess whether a clinical trial succeeded. It is pre-specified in the trial protocol and locked before unblinding. Common primary endpoints include overall survival, progression-free survival, HbA1c change, ACR20 response, and time to first cardiovascular event.
See also
- Surrogate endpoint — A measurable biomarker (e.g. tumour shrinkage, LDL) used as a proxy for a clinical benefit.