Last reviewed · How we verify
Zydelig
At a glance
| Generic name | Zydelig |
|---|---|
| Also known as | Idelalisib |
| Sponsor | University of Maryland, Baltimore |
| Target | DNA-dependent protein kinase catalytic subunit, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Approved indications
- Chronic lymphoid leukemia, disease
- Follicular non-Hodgkin's lymphoma
- Malignant lymphoma - small lymphocytic
Common side effects
- Diarrhea
- Pneumonia
- Pyrexia
- Fatigue
- Rash
- Cough
- Nausea
- Neutropenia
- ALT elevations
- AST elevations
Serious adverse events
- Pneumonia
- Diarrhea
- Pyrexia
- Sepsis
- Febrile neutropenia
- Hepatotoxicity
- Colitis
Key clinical trials
- A Study of DZD8586 Versus Investigator's Choice in r/r CLL/SLL (TAI-SHAN6) (PHASE3)
- A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (PHASE4)
- A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors (PHASE3)
- A Study of Idelalisib (GS1101, CAL101) + Ofatumumab in Previously Untreated CLL/SLL (PHASE2)
- A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis (PHASE2)
- A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL (PHASE3)
- A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL (PHASE1, PHASE2)
- ACY-1215 in Combination With BCR Pathway Inhibitors in Relapsed CLL (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |