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Pipracil (Piperacillin Sodium)
Piperacillin and tazobactam is an antibacterial drug combination.
Piperacillin and tazobactam is a combination penicillin-class antibacterial with beta-lactamase inhibitor indicated for multiple serious infections in adults and pediatric patients 2 months and older. The drug demonstrates time-dependent pharmacodynamics with short half-lives and approximately 30% protein binding. Significant drug interactions exist with aminoglycosides, probenecid, vancomycin, anticoagulants, and neuromuscular blockers requiring monitoring or separate administration. Use should be reserved for proven or strongly suspected bacterial infections to prevent resistance development.
At a glance
| Generic name | Piperacillin Sodium |
|---|---|
| Sponsor | Pfizer Inc. |
| Drug class | Penicillin-class antibacterial with beta-lactamase inhibitor |
| Target | Beta-lactamase producing bacteria |
| Modality | Small molecule |
| Phase | FDA-approved |
| First approval | 1981 |
Mechanism of action
Piperacillin is a penicillin-class antibacterial agent combined with tazobactam, a beta-lactamase inhibitor. The pharmacodynamic parameter most predictive of clinical and microbiological efficacy is time above MIC (minimum inhibitory concentration). This combination is designed to overcome beta-lactamase resistance mechanisms in susceptible bacterial pathogens.
Approved indications
- Abdominal abscess
- Acute gonococcal cervicitis
- Acute gonococcal endometritis
- Acute gonococcal urethritis
- Appendicitis
- Bacterial infection due to Klebsiella pneumoniae
- Bacterial infection due to Serratia
- Bacterial pneumonia
- Bacterial septicemia
- Bacteroides Appendicitis
- Bacteroides Complicated Appendicitis
- Bacteroides Endometritis
- Bacteroides Joint Infection
- Bacteroides Osteomyelitis
- Bacteroides Pelvic Cellulitis
- Bacteroides Pelvic Inflammatory Disease
- Bacteroides Peritonitis
- Bacteroides Pneumonia
- Cesarean Section Infection Prevention
- Clostridium Peritonitis
Boxed warnings
- PHARMACY BULK PACKAGE-NOT FOR DIRECT INFUSION
Common side effects
- Blood product related allergy
Drug interactions
- Tobramycin (aminoglycosides)
- Probenecid
- Vancomycin
- Heparin or oral anticoagulants
- Vecuronium and other non-depolarizing neuromuscular blockers
Patents
| Patent | Expiry | Type |
|---|---|---|
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pipracil CI brief — competitive landscape report
- Pipracil updates RSS · CI watch RSS
- Pfizer Inc. portfolio CI