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Sq. 26,991 (ZOFENOPRIL)
Sq. 26,991 (generic name: ZOFENOPRIL) is a zofenopril drug. It is currently in Phase 2 development for Hypertensive disorder.
Zofenopril works by blocking the action of angiotensin-converting enzyme, a key component in the renin-angiotensin-aldosterone system that regulates blood pressure.
Sq. 26991, also known as Zofenopril, is a small molecule. It is a medication with multiple synonyms, including Zofenopril, Zofenopril, Zofenopril, and Zofenopril.
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Baseline phase 2 → approval rate
+15.3pp
Industry-wide phase 2 drugs reach approval ~15.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas). -
Cardiovascular Phase 3 risk
-2.0pp
Modern cardiovascular outcome trials are large + long; many fail to beat aggressive standard-of-care.
| Regulator | Country | Likely year | Lag vs FDA |
|---|---|---|---|
| FDA | US | 2031–2034 | — |
| EMA | EU | 2032–2035 | +0.7 yr |
| MHRA | GB | 2032–2035 | +0.7 yr |
| Health Canada | CA | 2032–2036 | +0.9 yr |
| TGA | AU | 2032–2036 | +1.2 yr |
| PMDA | JP | 2032–2036 | +1.5 yr |
| NMPA | CN | 2033–2037 | +2.3 yr |
| MFDS | KR | 2032–2036 | +1.4 yr |
| CDSCO | IN | 2032–2037 | +1.8 yr |
| ANVISA | BR | 2033–2037 | +2.3 yr |
Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).
Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.
At a glance
| Generic name | ZOFENOPRIL |
|---|---|
| Drug class | zofenopril |
| Target | Angiotensin-converting enzyme |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 2 |
Mechanism of action
Think of the renin-angiotensin-aldosterone system like a plumbing system in your body. When you have high blood pressure, the pipes get clogged, and zofenopril helps to unclog them by blocking the enzyme that makes the pipes get clogged in the first place. This helps to lower your blood pressure and make it easier for your heart to pump blood.
Approved indications
- Hypertensive disorder
Common side effects
- Drug interaction
- Bradycardia
- Hyponatraemic syndrome
- Hypertensive crisis
- Vascular stent thrombosis
- Syncope
- Hallucination, gustatory
- Muscle contracture
- Dry mouth
Key clinical trials
- Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study
- Effectiveness and Safety of Combination of Amlodipine and Zofenopril in Hypertensive Patients Versus Each Monotherapy (PHASE4)
- Effectiveness and Safety of Combination of Nebivolol and Zofenopril in Hypertensive patIents Versus Each Monotherapy (PHASE4)
- NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients (PHASE4)
- Comparative Effects of Perindopril and Zofenopril on Blood Pressure Control and Oxidative Status Blacks Hypertensive Patients. (PHASE4)
- Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sq. 26,991 CI brief — competitive landscape report
- Sq. 26,991 updates RSS · CI watch RSS
Frequently asked questions about Sq. 26,991
What is Sq. 26,991?
How does Sq. 26,991 work?
What is Sq. 26,991 used for?
What is the generic name of Sq. 26,991?
What drug class is Sq. 26,991 in?
What development phase is Sq. 26,991 in?
What are the side effects of Sq. 26,991?
What does Sq. 26,991 target?
Related
- Drug class: All zofenopril drugs
- Target: All drugs targeting Angiotensin-converting enzyme
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertensive disorder
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing