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Xylocaine and Dexamethasone
Xylocaine (lidocaine) blocks nerve conduction by inhibiting sodium channels, while dexamethasone suppresses inflammatory and immune responses through glucocorticoid receptor activation.
Xylocaine (lidocaine) blocks nerve conduction by inhibiting sodium channels, while dexamethasone suppresses inflammatory and immune responses through glucocorticoid receptor activation. Used for Local anesthesia with anti-inflammatory effect (specific indication not clearly defined in available literature).
At a glance
| Generic name | Xylocaine and Dexamethasone |
|---|---|
| Also known as | XD |
| Sponsor | University of Jordan |
| Drug class | Local anesthetic + corticosteroid combination |
| Target | Voltage-gated sodium channels (lidocaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Inflammation, Local anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that reversibly inhibits voltage-gated sodium channels in nerve membranes, preventing action potential propagation and pain signal transmission. Dexamethasone is a potent corticosteroid that binds glucocorticoid receptors to reduce inflammation, suppress immune cell activation, and decrease production of inflammatory mediators. Together, this combination provides both local anesthetic and anti-inflammatory effects.
Approved indications
- Local anesthesia with anti-inflammatory effect (specific indication not clearly defined in available literature)
Common side effects
- Local irritation or burning at injection site
- Systemic corticosteroid effects (with repeated use)
- Allergic reaction to lidocaine
- Methemoglobinemia (rare, with lidocaine)
Key clinical trials
- Predictors of Treatment Response to Stellate Ganglion Block in Cervical Radicular Pain
- Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study) (PHASE2)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy (PHASE3)
- Pericapsular Nerve Group Block Added to Intra-articular Corticosteroid Injection in the Treatment of Hip Pain
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Xylocaine and Dexamethasone CI brief — competitive landscape report
- Xylocaine and Dexamethasone updates RSS · CI watch RSS
- University of Jordan portfolio CI