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Xylitol only chewing gum
Xylitol in chewing gum reduces cavity-causing bacteria in the mouth by inhibiting their metabolism and adhesion to tooth surfaces.
Xylitol in chewing gum reduces cavity-causing bacteria in the mouth by inhibiting their metabolism and adhesion to tooth surfaces. Used for Dental caries prevention.
At a glance
| Generic name | Xylitol only chewing gum |
|---|---|
| Sponsor | The University of Texas Health Science Center, Houston |
| Drug class | Caries preventive agent |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Xylitol is a sugar alcohol that cannot be fermented by oral cariogenic bacteria (particularly Streptococcus mutans), preventing acid production that leads to tooth decay. Additionally, xylitol has antimicrobial properties that reduce bacterial colonization and biofilm formation on teeth. Regular chewing of xylitol-containing gum stimulates saliva flow, which further protects teeth through natural buffering and remineralization.
Approved indications
- Dental caries prevention
Common side effects
- Gastrointestinal distress (if swallowed in large quantities)
- Laxative effect
Key clinical trials
- The Effect of Chewing Gum on Nausea, Vomiting and Bowel Function After Colorectal Surgery (NA)
- Effect of Different Products to Support Plaque Control During Daytime (NA)
- Effect of Gum Chewing or Walking on Bowel Prep Quality and Patient Satisfaction Before Colonoscopy (NA)
- Effect of Gum Chewing on Sore Throat After Double-lumen Tube Intubation (NA)
- Effect of Xylitol Gum Chewing on Postoperative Bowel Activity (NA)
- Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis (PHASE4)
- Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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