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vonoprazan fumarate + amoxicillin（H-14d)

Sixth Affiliated Hospital, Sun Yat-sen University · Phase 3 active Small molecule

vonoprazan fumarate + amoxicillin（H-14d) is a Proton pump inhibitor + beta-lactam antibiotic combination Small molecule drug developed by Sixth Affiliated Hospital, Sun Yat-sen University. It is currently in Phase 3 development for Helicobacter pylori eradication in infected patients (H-14d regimen).

Vonoprazan fumarate inhibits gastric acid secretion by blocking the proton pump, while amoxicillin is a beta-lactam antibiotic that kills Helicobacter pylori bacteria.

Vonoprazan fumarate inhibits gastric acid secretion by blocking the proton pump, while amoxicillin is a beta-lactam antibiotic that kills Helicobacter pylori bacteria. Used for Helicobacter pylori eradication in infected patients (H-14d regimen).

At a glance

Generic namevonoprazan fumarate + amoxicillin（H-14d)
SponsorSixth Affiliated Hospital, Sun Yat-sen University
Drug classProton pump inhibitor + beta-lactam antibiotic combination
TargetH+/K+-ATPase (vonoprazan); bacterial cell wall (amoxicillin)
ModalitySmall molecule
Therapeutic areaGastroenterology / Infectious Disease
PhasePhase 3

Mechanism of action

This combination therapy targets H. pylori eradication by creating an acidic environment unfavorable for bacterial survival (via vonoprazan) while simultaneously delivering bactericidal antibiotic activity (via amoxicillin). Vonoprazan is a potassium-competitive acid blocker (P-CAB) that provides more rapid and sustained acid suppression than traditional proton pump inhibitors, enhancing amoxicillin's efficacy against H. pylori.

Approved indications

Common side effects

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Frequently asked questions about vonoprazan fumarate + amoxicillin（H-14d)

What is vonoprazan fumarate + amoxicillin（H-14d)?

vonoprazan fumarate + amoxicillin（H-14d) is a Proton pump inhibitor + beta-lactam antibiotic combination drug developed by Sixth Affiliated Hospital, Sun Yat-sen University, indicated for Helicobacter pylori eradication in infected patients (H-14d regimen).

How does vonoprazan fumarate + amoxicillin（H-14d) work?

Vonoprazan fumarate inhibits gastric acid secretion by blocking the proton pump, while amoxicillin is a beta-lactam antibiotic that kills Helicobacter pylori bacteria.

What is vonoprazan fumarate + amoxicillin（H-14d) used for?

vonoprazan fumarate + amoxicillin（H-14d) is indicated for Helicobacter pylori eradication in infected patients (H-14d regimen).

Who makes vonoprazan fumarate + amoxicillin（H-14d)?

vonoprazan fumarate + amoxicillin（H-14d) is developed by Sixth Affiliated Hospital, Sun Yat-sen University (see full Sixth Affiliated Hospital, Sun Yat-sen University pipeline at /company/sixth-affiliated-hospital-sun-yat-sen-university).

What drug class is vonoprazan fumarate + amoxicillin（H-14d) in?

vonoprazan fumarate + amoxicillin（H-14d) belongs to the Proton pump inhibitor + beta-lactam antibiotic combination class. See all Proton pump inhibitor + beta-lactam antibiotic combination drugs at /class/proton-pump-inhibitor-beta-lactam-antibiotic-combination.

What development phase is vonoprazan fumarate + amoxicillin（H-14d) in?

vonoprazan fumarate + amoxicillin（H-14d) is in Phase 3.

What are the side effects of vonoprazan fumarate + amoxicillin（H-14d)?

Common side effects of vonoprazan fumarate + amoxicillin（H-14d) include Diarrhea, Nausea, Abdominal discomfort, Headache, Allergic reactions (amoxicillin-related).

What does vonoprazan fumarate + amoxicillin（H-14d) target?

vonoprazan fumarate + amoxicillin（H-14d) targets H+/K+-ATPase (vonoprazan); bacterial cell wall (amoxicillin) and is a Proton pump inhibitor + beta-lactam antibiotic combination.

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