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Vitamins: Folic acid, B6, B12
These B vitamins (folic acid, B6, and B12) serve as essential cofactors in one-carbon metabolism and homocysteine regulation, supporting DNA synthesis, methylation reactions, and neurological function.
These B vitamins (folic acid, B6, and B12) serve as essential cofactors in one-carbon metabolism and homocysteine regulation, supporting DNA synthesis, methylation reactions, and neurological function. Used for Folic acid deficiency and prevention of neural tube defects in pregnancy, Vitamin B12 deficiency and pernicious anemia, Vitamin B6 deficiency.
At a glance
| Generic name | Vitamins: Folic acid, B6, B12 |
|---|---|
| Sponsor | Hamilton Health Sciences Corporation |
| Drug class | Vitamin supplement / B-complex |
| Modality | Small molecule |
| Therapeutic area | Nutritional supplementation / Preventive health |
| Phase | FDA-approved |
Mechanism of action
Folic acid and B12 are critical for DNA synthesis and cell division, while B6 (pyridoxine) acts as a cofactor in amino acid metabolism and neurotransmitter synthesis. Together, these vitamins help regulate homocysteine levels by facilitating its conversion to methionine, reducing cardiovascular and neurological risk. They are essential micronutrients required for normal hematopoiesis, nervous system function, and cellular metabolism.
Approved indications
- Folic acid deficiency and prevention of neural tube defects in pregnancy
- Vitamin B12 deficiency and pernicious anemia
- Vitamin B6 deficiency
- Homocysteine reduction and cardiovascular risk reduction
- General nutritional supplementation
Common side effects
- Nausea
- Headache
- Paresthesia (with high-dose B6)
- Allergic reactions (rare)
Key clinical trials
- A Study Evaluating Quality of Life Parameters Following Use of Emergen-C (PHASE4)
- Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease (NA)
- Chemo Brain Prehab Project (NA)
- Alii Supplement Study (PHASE2)
- B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy. (NA)
- A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome (NA)
- Micronutrient Dose Response Study in Bangladesh (NA)
- The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vitamins: Folic acid, B6, B12 CI brief — competitive landscape report
- Vitamins: Folic acid, B6, B12 updates RSS · CI watch RSS
- Hamilton Health Sciences Corporation portfolio CI