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Vitamin D and calcium supplementation
Vitamin D and calcium supplementation work together to promote bone mineralization and maintain serum calcium levels by enhancing intestinal calcium absorption and regulating calcium-phosphate homeostasis.
Vitamin D and calcium supplementation work together to promote bone mineralization and maintain serum calcium levels by enhancing intestinal calcium absorption and regulating calcium-phosphate homeostasis. Used for Osteoporosis prevention and treatment, Vitamin D deficiency, Hypocalcemia.
At a glance
| Generic name | Vitamin D and calcium supplementation |
|---|---|
| Sponsor | Hoffmann-La Roche |
| Drug class | Nutritional supplement / mineral and vitamin combination |
| Target | Vitamin D receptor (VDR); calcium ion channels and transporters |
| Modality | Small molecule |
| Therapeutic area | Bone health / Musculoskeletal |
| Phase | FDA-approved |
Mechanism of action
Vitamin D (cholecalciferol or ergocalciferol) is metabolized to its active form, calcitriol, which increases intestinal absorption of dietary calcium and phosphate. Calcium supplementation provides the mineral substrate necessary for bone formation and maintenance. Together, they support skeletal health by ensuring adequate mineral availability and preventing secondary hyperparathyroidism.
Approved indications
- Osteoporosis prevention and treatment
- Vitamin D deficiency
- Hypocalcemia
- Bone health maintenance in aging populations
Common side effects
- Hypercalcemia
- Gastrointestinal upset (nausea, constipation)
- Kidney stone formation
- Hypercalciuria
Key clinical trials
- PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery" (NA)
- Effects of Vitamin D and Calcium on Hyperglycemia and Dyslipidemia in Patients Gestational Diabetes (NA)
- Study of Vitamin D Supplementation Tailored to Vitamin D Deficiency in Breast Cancer Patients (PHASE3)
- Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer (PHASE3)
- Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes (PHASE2)
- Setrusumab vs Placebo for Osteogenesis Imperfecta (PHASE2, PHASE3)
- This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65. (NA)
- Parathyroidectomy After Kidney Transplantation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vitamin D and calcium supplementation CI brief — competitive landscape report
- Vitamin D and calcium supplementation updates RSS · CI watch RSS
- Hoffmann-La Roche portfolio CI