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vitamin B6 (pyridoxine)
Vitamin B6 (pyridoxine) acts as a coenzyme in amino acid metabolism, neurotransmitter synthesis, and hemoglobin formation.
Vitamin B6 (pyridoxine) acts as a coenzyme in amino acid metabolism, neurotransmitter synthesis, and hemoglobin formation. Used for Vitamin B6 deficiency, Homocysteinemia, Peripheral neuropathy.
At a glance
| Generic name | vitamin B6 (pyridoxine) |
|---|---|
| Sponsor | Haukeland University Hospital |
| Drug class | Vitamin B complex |
| Target | Pyridoxal-5-phosphate-dependent enzymes |
| Modality | Small molecule |
| Therapeutic area | Nutritional/Metabolic |
| Phase | FDA-approved |
Mechanism of action
Pyridoxine is converted to its active form, pyridoxal-5-phosphate (PLP), which serves as a cofactor for over 100 enzymes involved in protein metabolism, neurotransmitter production (serotonin, dopamine, GABA), and immune function. It is essential for the synthesis of hemoglobin and myelin, and plays a critical role in homocysteine metabolism.
Approved indications
- Vitamin B6 deficiency
- Homocysteinemia
- Peripheral neuropathy
- Premenstrual syndrome
- Nausea and vomiting in pregnancy
Common side effects
- Peripheral neuropathy (at high doses >200 mg/day)
- Sensory ataxia (at high doses)
- Photosensitivity (rare)
Key clinical trials
- The Acute Effects of Onnit Alpha Brain on Cognition and Mood States (NA)
- An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM (PHASE3)
- The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms (NA)
- Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion (EARLY_PHASE1)
- Testing the Efficacy of 100mg Vitamin-B6 Daily for Sensory Reactivity in Autism (NA)
- The Effects of Vitamin B6 Supplementation on Pain Thresholds and Tolerance (PHASE1)
- A Study Evaluating Quality of Life Parameters Following Use of Emergen-C (PHASE4)
- The Effect of Pyridoxamine Supplementation on Microvascular Function in Type 2 Diabetes (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- vitamin B6 (pyridoxine) CI brief — competitive landscape report
- vitamin B6 (pyridoxine) updates RSS · CI watch RSS
- Haukeland University Hospital portfolio CI