Last reviewed 2026-04-22 · How we verify

VIP

VIP (Vasoactive Intestinal Peptide) is a neuropeptide that acts as a vasodilator and neuromodulator to reduce migraine and headache symptoms.

VIP (Vasoactive Intestinal Peptide) is a neuropeptide that acts as a vasodilator and neuromodulator to reduce migraine and headache symptoms. Used for Migraine, Cluster headache, Tension-type headache.

At a glance

Mechanism of action

VIP binds to VIP receptors on vascular and neuronal tissues, promoting vasodilation and modulating pain signaling pathways involved in migraine pathophysiology. By reducing neurogenic inflammation and stabilizing cerebral blood flow, VIP addresses multiple mechanisms underlying headache disorders. The peptide's neuromodulatory effects help normalize pain processing in the trigeminal system.

Approved indications

• Migraine
• Cluster headache
• Tension-type headache

Common side effects

• Flushing
• Headache exacerbation
• Dizziness

Key clinical trials

• Comparison of the Frequency of Ventilator-Associated Pneumonia in Intubated Patients Followed Up With Automatic Cuff Pressure Controller and Manual Cuff Pressure Controller in Pediatric Intensive Care
• Investigation Into Detection of Prostate Cancer Using Voided Urine (Prostate VPAC)
• Yield of Diagnostic Tests and Effects of Crofelemer for Chronic Idiopathic Diarrhea In Non-HIV Patients (PHASE4)
• IBIS Megastudy of Interventions to Encourage HIV Retesting (NA)
• IBIS Megastudy- Pilot (NA)
• V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency (PHASE3)
• The Virtual Promotoras Study: eHealth Intervention to Promote Sexual Health Among Young Latina Women in the US South (NA)
• Von Willebrand Factor in Pregnancy (VIP) Study

Primary sources

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