Last reviewed · How we verify
Vincristine, Carboplatin and Etoposide
Vincristine, Carboplatin and Etoposide is a Combination chemotherapy (vinca alkaloid + platinum agent + topoisomerase II inhibitor) Small molecule drug developed by St. Jude Children's Research Hospital. It is currently in Phase 3 development for Pediatric cancers (likely lymphomas, leukemias, or solid tumors based on St. Jude focus). Also known as: Onconvin and Paraplatin and Vepesid.
This combination chemotherapy regimen kills cancer cells by disrupting microtubule formation (vincristine), damaging DNA (carboplatin), and inhibiting topoisomerase II (etoposide).
This combination chemotherapy regimen kills cancer cells by disrupting microtubule formation (vincristine), damaging DNA (carboplatin), and inhibiting topoisomerase II (etoposide). Used for Pediatric cancers (likely lymphomas, leukemias, or solid tumors based on St. Jude focus).
At a glance
| Generic name | Vincristine, Carboplatin and Etoposide |
|---|---|
| Also known as | Onconvin and Paraplatin and Vepesid |
| Sponsor | St. Jude Children's Research Hospital |
| Drug class | Combination chemotherapy (vinca alkaloid + platinum agent + topoisomerase II inhibitor) |
| Target | Tubulin (vincristine), DNA (carboplatin), Topoisomerase II (etoposide) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Vincristine is a vinca alkaloid that binds tubulin and prevents microtubule assembly, arresting cells in metaphase. Carboplatin is a platinum-based agent that forms DNA crosslinks, causing strand breaks and cell death. Etoposide is a topoisomerase II inhibitor that prevents DNA religation, leading to double-strand breaks. Together, these agents provide synergistic cytotoxic activity against rapidly dividing cancer cells.
Approved indications
- Pediatric cancers (likely lymphomas, leukemias, or solid tumors based on St. Jude focus)
Common side effects
- Myelosuppression (neutropenia, thrombocytopenia, anemia)
- Nausea and vomiting
- Peripheral neuropathy
- Alopecia
- Mucositis
- Infection
Key clinical trials
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma (PHASE3)
- Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (PHASE2)
- Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) (PHASE1)
- A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) (PHASE3)
- Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL) (PHASE1, PHASE2)
- Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) (PHASE3)
- Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation (EARLY_PHASE1)
- A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vincristine, Carboplatin and Etoposide CI brief — competitive landscape report
- Vincristine, Carboplatin and Etoposide updates RSS · CI watch RSS
- St. Jude Children's Research Hospital portfolio CI
Frequently asked questions about Vincristine, Carboplatin and Etoposide
What is Vincristine, Carboplatin and Etoposide?
How does Vincristine, Carboplatin and Etoposide work?
What is Vincristine, Carboplatin and Etoposide used for?
Who makes Vincristine, Carboplatin and Etoposide?
Is Vincristine, Carboplatin and Etoposide also known as anything else?
What drug class is Vincristine, Carboplatin and Etoposide in?
What development phase is Vincristine, Carboplatin and Etoposide in?
What are the side effects of Vincristine, Carboplatin and Etoposide?
What does Vincristine, Carboplatin and Etoposide target?
Related
- Drug class: All Combination chemotherapy (vinca alkaloid + platinum agent + topoisomerase II inhibitor) drugs
- Target: All drugs targeting Tubulin (vincristine), DNA (carboplatin), Topoisomerase II (etoposide)
- Manufacturer: St. Jude Children's Research Hospital — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Pediatric cancers (likely lymphomas, leukemias, or solid tumors based on St. Jude focus)
- Also known as: Onconvin and Paraplatin and Vepesid
- Compare: Vincristine, Carboplatin and Etoposide vs similar drugs
- Pricing: Vincristine, Carboplatin and Etoposide cost, discount & access