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Vildagliptin (Galvus)
Vildagliptin (Galvus) is a DPP-4 inhibitor Small molecule drug developed by University Hospital, Strasbourg, France. It is currently FDA-approved for Type 2 diabetes mellitus as monotherapy or in combination with other antidiabetic agents.
Vildagliptin inhibits dipeptidyl peptidase-4 (DPP-4), allowing incretin hormones to accumulate and stimulate insulin secretion in response to glucose.
Vildagliptin, also known as Galvus, is a small molecule dipeptidyl peptidase IV inhibitor used to treat conditions such as type-2 diabetes. It belongs to the drug class of inhibitors and has been studied in various clinical trials, including those for type-2 diabetes and proteinuria.
At a glance
| Generic name | Vildagliptin (Galvus) |
|---|---|
| Sponsor | University Hospital, Strasbourg, France |
| Drug class | DPP-4 inhibitor |
| Target | DPP-4 (dipeptidyl peptidase-4) |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | FDA-approved |
Mechanism of action
DPP-4 normally degrades glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that enhance postprandial insulin secretion. By blocking DPP-4, vildagliptin prolongs the action of these hormones, leading to improved glycemic control in a glucose-dependent manner. This mechanism reduces hypoglycemia risk compared to insulin secretagogues.
Approved indications
- Type 2 diabetes mellitus as monotherapy or in combination with other antidiabetic agents
Common side effects
- Headache
- Nasopharyngitis
- Dizziness
- Hypoglycemia (when combined with insulin or sulfonylureas)
Key clinical trials
- A Prospective, Multicenter, Randomized, Open-label Study of 12 Week Duration to Evaluate the Effect of VILDagliptin Added to Insulin on Glycaemic Control in haemoDIALyzed Patients With Type 2 Diabetes: Probe Analysis of CGM (PHASE4)
- Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. (PHASE4)
- Efficacy of Vildagliptin Versus Metformin in Poly Cystic Ovary Syndrome (PHASE2, PHASE3)
- Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients (PHASE2)
- Effect of Vildagliptin Versus Dapagliflozin as Add on Therapy to Metformin on Cardiovascular Risk Factors (PHASE4)
- Vildagliptin for Treatment of Antipsychotic-induced Dyslipidemia (PHASE2)
- The DPP-4 Inhibitor Vildagliptin as Adjunct in Major Depressive Disorder Patients (PHASE1, PHASE2)
- A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vildagliptin (Galvus) CI brief — competitive landscape report
- Vildagliptin (Galvus) updates RSS · CI watch RSS
- University Hospital, Strasbourg, France portfolio CI
Frequently asked questions about Vildagliptin (Galvus)
What is Vildagliptin (Galvus)?
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Who makes Vildagliptin (Galvus)?
What drug class is Vildagliptin (Galvus) in?
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What does Vildagliptin (Galvus) target?
Related
- Drug class: All DPP-4 inhibitor drugs
- Target: All drugs targeting DPP-4 (dipeptidyl peptidase-4)
- Manufacturer: University Hospital, Strasbourg, France — full pipeline
- Therapeutic area: All drugs in Diabetes
- Indication: Drugs for Type 2 diabetes mellitus as monotherapy or in combination with other antidiabetic agents
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing