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Vehicle control
A vehicle control is an inert formulation used as a negative control in clinical studies to establish baseline effects and distinguish drug-specific activity from placebo or formulation effects.
At a glance
| Generic name | Vehicle control |
|---|---|
| Also known as | Vehicle, Placebo, placebo |
| Sponsor | University of Reading |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
Vehicle controls contain the same inactive ingredients and excipients as the active drug formulation but without the active pharmaceutical ingredient. They are used in comparative studies to isolate the true pharmacological effect of the drug from effects caused by the delivery system, excipients, or non-specific factors. This is a standard research tool rather than a therapeutic agent.
Approved indications
Common side effects
Key clinical trials
- Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-IIb Trial) (PHASE2)
- A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic Keratosis (PHASE3)
- AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension (PHASE1, PHASE2)
- TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD (PHASE1, PHASE2)
- Melatonin for Treatment of Delirium in Critically Ill Adult Patients (PHASE2)
- The ASCEND Study: Evaluating TMB-001 in the Treatment of RXLI or ARCI Ichthyosis (PHASE3)
- Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa (PHASE3)
- A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE). (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vehicle control CI brief — competitive landscape report
- Vehicle control updates RSS · CI watch RSS
- University of Reading portfolio CI