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vasopressin - early initiation
Vasopressin is a naturally occurring hormone that binds to vasopressin receptors to increase blood pressure and vasoconstriction, used in early septic shock management to restore hemodynamic stability.
Vasopressin is a naturally occurring hormone that binds to vasopressin receptors to increase blood pressure and vasoconstriction, used in early septic shock management to restore hemodynamic stability. Used for Septic shock (early initiation for hemodynamic support), Variceal bleeding.
At a glance
| Generic name | vasopressin - early initiation |
|---|---|
| Also known as | vasopressin |
| Sponsor | The Cleveland Clinic |
| Drug class | Vasopressor agent |
| Target | Vasopressin receptor (V1 and V2) |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Sepsis |
| Phase | FDA-approved |
Mechanism of action
Vasopressin acts as a potent vasoconstrictor by activating V1 receptors on vascular smooth muscle cells, leading to increased systemic vascular resistance and blood pressure. Early initiation in septic shock aims to rapidly restore perfusion pressure and reduce the need for catecholamine vasopressors. The hormone also has antidiuretic effects through V2 receptor activation in the kidney, helping maintain fluid balance.
Approved indications
- Septic shock (early initiation for hemodynamic support)
- Variceal bleeding
Common side effects
- Peripheral vasoconstriction / ischemia
- Hyponatremia
- Coronary vasoconstriction
- Arrhythmias
Key clinical trials
- Early Versus Late Adjunctive Vasopressin in Septic Shock (PHASE4)
- Multimodal Vasopressor Strategy in Septic Shock (PHASE2, PHASE3)
- Hemodynamics and Extravascular Lung Water in Acute Lung Injury (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- vasopressin - early initiation CI brief — competitive landscape report
- vasopressin - early initiation updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI