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Vasoactive drug therapy
Vasoactive drug therapy uses pharmacological agents to modulate vascular tone and blood flow by acting on smooth muscle and endothelial function.
Vasoactive drug therapy uses pharmacological agents to modulate vascular tone and blood flow by acting on smooth muscle and endothelial function. Used for Hemodynamic support in critically ill patients, Shock management (septic, cardiogenic, hypovolemic), Acute hypotension.
At a glance
| Generic name | Vasoactive drug therapy |
|---|---|
| Also known as | Norepinephrine, epinephrine, metaraminol, isoproterenol |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Drug class | Vasoactive agent (class includes vasopressors, inotropes, and vasodilators) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Vasoactive drugs work by stimulating or inhibiting adrenergic receptors, nitric oxide pathways, or other vascular regulatory mechanisms to either constrict or dilate blood vessels. These agents are used to manage hemodynamic instability by increasing or decreasing systemic vascular resistance and cardiac output as needed in acute care settings.
Approved indications
- Hemodynamic support in critically ill patients
- Shock management (septic, cardiogenic, hypovolemic)
- Acute hypotension
Common side effects
- Tachycardia
- Arrhythmias
- Hypertension
- Tissue necrosis at infusion site
- Peripheral vasoconstriction
Key clinical trials
- Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery (NA)
- Investigation Into Detection of Prostate Cancer Using Voided Urine (Prostate VPAC)
- CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock (PHASE2)
- International Care Bundle Evaluation in Cerebral Hemorrhage Research (PHASE4)
- Correlation Between EIT-based Pulse Wave Method for Pulmonary Perfusion Monitoring and Pulmonary Artery Catheter-based Stroke Volume Measurement
- Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines (NA)
- Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography
- Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |