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Vancomycin and Tobramycin
Vancomycin and tobramycin are a combination of two antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein synthesis, respectively, to treat infections in trauma patients.
Vancomycin and tobramycin are a combination of two antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein synthesis, respectively, to treat infections in trauma patients. Used for Infection prophylaxis and treatment in major extremity trauma, Polymicrobial infections in trauma patients.
At a glance
| Generic name | Vancomycin and Tobramycin |
|---|---|
| Sponsor | Major Extremity Trauma Research Consortium |
| Drug class | Antibiotic combination (glycopeptide + aminoglycoside) |
| Target | Bacterial cell wall (vancomycin) and 30S ribosomal subunit (tobramycin) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Trauma Surgery |
| Phase | Phase 3 |
Mechanism of action
Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala peptidoglycan precursors, while tobramycin is an aminoglycoside that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Together, they provide broad-spectrum coverage against gram-positive and gram-negative organisms commonly encountered in major trauma and extremity injuries.
Approved indications
- Infection prophylaxis and treatment in major extremity trauma
- Polymicrobial infections in trauma patients
Common side effects
- Nephrotoxicity
- Ototoxicity
- Red man syndrome (vancomycin)
- Infusion-related reactions
Key clinical trials
- Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection (NA)
- Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial (PHASE2)
- Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy (PHASE3)
- Acute Application of Antibiotic Powder in Open Fracture Wounds (PHASE4)
- Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA (PHASE3)
- Local Antibiotic Concentrations With Tissue Expanders in Breast Reconstruction (NA)
- Intramedullary Calcium Sulfate Antibiotic Depot (PHASE3)
- Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |