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Vancomycin and Gentamicin
Vancomycin and gentamicin are a combination antibiotic regimen that inhibits bacterial cell wall synthesis and protein synthesis to treat serious infections.
Vancomycin and gentamicin are a combination antibiotic regimen that inhibits bacterial cell wall synthesis and protein synthesis to treat serious infections. Used for Empiric treatment of febrile neutropenia in cancer patients, Serious gram-positive and gram-negative bacterial infections in immunocompromised hosts.
At a glance
| Generic name | Vancomycin and Gentamicin |
|---|---|
| Sponsor | Memorial Sloan Kettering Cancer Center |
| Drug class | Antibiotic combination (glycopeptide + aminoglycoside) |
| Target | Bacterial cell wall (vancomycin) and bacterial 30S ribosome (gentamicin) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall peptidoglycan cross-linking, primarily effective against gram-positive organisms. Gentamicin is an aminoglycoside that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This combination is used empirically for synergistic coverage of serious infections, particularly in immunocompromised patients such as those with cancer.
Approved indications
- Empiric treatment of febrile neutropenia in cancer patients
- Serious gram-positive and gram-negative bacterial infections in immunocompromised hosts
Common side effects
- Nephrotoxicity
- Ototoxicity
- Infusion-related reactions (vancomycin)
- Electrolyte abnormalities
- Elevated liver enzymes
Key clinical trials
- Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial (PHASE4)
- Local Antibiotics for Breast Implants (PHASE3)
- Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (PHASE3)
- Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial (PHASE4)
- Intramedullary Calcium Sulfate Antibiotic Depot (PHASE3)
- A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement (PHASE4)
- TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden (PHASE3)
- Using Antibiotics to Prevent Infections in Hemodialysis Patients During Catheter Placement (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vancomycin and Gentamicin CI brief — competitive landscape report
- Vancomycin and Gentamicin updates RSS · CI watch RSS
- Memorial Sloan Kettering Cancer Center portfolio CI