Last reviewed 2026-04-23 · How we verify

Valproate, Levocarnitine

Valproate is a mood stabilizer that works by reducing the activity of certain brain chemicals, while Levocarnitine is involved in energy production within cells.

Valproate is a mood stabilizer that works by reducing the activity of certain brain chemicals, while Levocarnitine is involved in energy production within cells. Used for Seizure prevention, Mania treatment.

At a glance

Mechanism of action

Valproate is thought to exert its effects by inhibiting the reuptake of certain neurotransmitters, such as serotonin and dopamine, and by reducing the release of excitatory neurotransmitters. Levocarnitine plays a crucial role in the transport of fatty acids into mitochondria, where they can be used as energy sources.

Approved indications

• Seizure prevention, Mania treatment

Common side effects

• Nausea
• Dizziness
• Headache
• Fatigue
• Weight gain
• Hair loss
• Liver enzyme elevation
• Pancreatitis
• Thrombocytopenia
• Leukopenia

Key clinical trials

• Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy (PHASE2)
• Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy (PHASE2)
• Valproate and Levocarnitine in Children With Spinal Muscular Atrophy (PHASE3)
• CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type I (PHASE1, PHASE2)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Valproate, Levocarnitine CI brief — competitive landscape report
• Valproate, Levocarnitine updates RSS · CI watch RSS
• All India Institute of Medical Sciences portfolio CI