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Vaginal Estrogen - Daily
Estrogen replacement therapy to alleviate menopausal symptoms.
Estrogen replacement therapy to alleviate menopausal symptoms. Used for Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause or breast cancer treatment.
At a glance
| Generic name | Vaginal Estrogen - Daily |
|---|---|
| Also known as | Conjugated Estrogens CSD, 0.625 mg/g, Vaginal Cream |
| Sponsor | Queen's University |
| Drug class | estrogen replacement therapy |
| Modality | Small molecule |
| Therapeutic area | Women's Health |
| Phase | Phase 3 |
Mechanism of action
Vaginal estrogen therapy works by releasing estrogen directly into the vagina, which helps to restore the natural balance of estrogen in the body. This can help to alleviate symptoms such as vaginal dryness, itching, and burning, as well as hot flashes and night sweats.
Approved indications
- Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause or breast cancer treatment
Common side effects
- Vaginal discharge
- Vaginal bleeding
- Headache
Key clinical trials
- Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency (PHASE3)
- Postpartum Vaginal Estrogen for Breastfeeding Patients (PHASE4)
- FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles (NA)
- A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion (NA)
- Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause (NA)
- Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder (PHASE4)
- Vaginal Care System for Menopausal Women With Urinary Tract Infections (NA)
- Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vaginal Estrogen - Daily CI brief — competitive landscape report
- Vaginal Estrogen - Daily updates RSS · CI watch RSS
- Queen's University portfolio CI