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Usual Care Inhaled Glucocorticosteroids
Inhaled glucocorticosteroids reduce airway inflammation by binding to glucocorticoid receptors in lung tissue, suppressing inflammatory cytokine production and immune cell activation.
Inhaled glucocorticosteroids reduce airway inflammation by binding to glucocorticoid receptors in lung tissue, suppressing inflammatory cytokine production and immune cell activation. Used for Asthma maintenance therapy, Chronic obstructive pulmonary disease (COPD).
At a glance
| Generic name | Usual Care Inhaled Glucocorticosteroids |
|---|---|
| Sponsor | AstraZeneca |
| Drug class | Inhaled corticosteroid (ICS) |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Respiratory / Pulmonology |
| Phase | FDA-approved |
Mechanism of action
Glucocorticosteroids are potent anti-inflammatory agents that work by translocating to the nucleus and modulating gene expression of inflammatory mediators. When inhaled directly into the lungs, they achieve high local concentrations while minimizing systemic exposure, reducing airway inflammation, mucus production, and bronchial hyperresponsiveness in asthma and COPD.
Approved indications
- Asthma maintenance therapy
- Chronic obstructive pulmonary disease (COPD)
Common side effects
- Oral candidiasis (thrush)
- Hoarseness
- Tremor (from beta-agonist co-administration)
- Headache
- Dysphonia
Key clinical trials
- Inhaled Long-acting Bronchodilators With or Without Inhaled Glucocorticosteroids for Preventing Hospitalizations and Death in Elderly Patients With Chronic Obstructive Pulmonary Disease (PHASE4)
- Asthma Care With Alvesco® (Ciclesonide) in Primary Care in Adults - The ACCEPT-study (BY9010/CA-102) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Usual Care Inhaled Glucocorticosteroids CI brief — competitive landscape report
- Usual Care Inhaled Glucocorticosteroids updates RSS · CI watch RSS
- AstraZeneca portfolio CI